Changes in synaptic inputs to dI3 INs and MNs after complete transection in adult mice
نویسندگان
چکیده
Introduction Spinal cord injury (SCI) is a debilitating condition that disrupts the communication between brain and spinal cord. Several studies have sought to determine how revive dormant circuits caudal lesion restore movements in paralyzed patients. So far, recovery levels human patients been modest at best. In contrast, animal models of SCI exhibit more lost function. Previous work from our lab has identified dI3 interneurons as neuron population central locomotor function spinalized mice. We seek changes circuitry motoneurons following adult Methods After complete transection T9-T11 level transgenic Isl1:YFP mice subsequent treadmill training various time points surgery, we examined three key involving motoneurons: (1) Sensory inputs proprioceptive cutaneous afferents, (2) Presynaptic inhibition sensory inputs, (3) Central excitatory glutamatergic synapses neurons onto INs motoneurons. Furthermore, possible role on synaptic connectivity Results Our data suggests VGLUT1 + decrease transiently or only later stages after injury, whereas remain same for injury. Levels VGLUT2 MNs may show transient increases but fall below seen sham-operated period time. presynaptic can rise shortly SCI, those do not persist. However, never fell observed For some studied, were higher cord-injured animals received training, these points. Discussion These results suggest remodeling previously implicated
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ژورنال
عنوان ژورنال: Frontiers in Neural Circuits
سال: 2023
ISSN: ['1662-5110']
DOI: https://doi.org/10.3389/fncir.2023.1176310